Protein Variants | Comment | Organism |
---|---|---|
additional information | inhibition of HO-1 expression by small interfering RNA decreases cellular survival and apoptosis in the mouse hepatoma cell lines Hepa129 and Hepa1-6, and orthotopic tumor growth in immune-competent C3H/HeN mice, mechanism. But application of siHO1 does not induce liver or kidney damage in mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Mus musculus | endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | Mus musculus C3H/HEN | endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | Mus musculus | inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview | ? | - |
? | |
additional information | Mus musculus C3H/HEN | inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P14901 | C3H/HeN mice | - |
Mus musculus C3H/HEN | P14901 | C3H/HeN mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
hepatoma cell | overexpression of HO-1 | Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression | Mus musculus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | - |
Mus musculus C3H/HEN | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | endogenous HO-1 shows anti-apoptotic activity, and is overexpressed in various cancer diseases and might contribute to cancer progression | Mus musculus C3H/HEN | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
additional information | inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview | Mus musculus | ? | - |
? | |
additional information | inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic hepatocellular carcinoma and reduced angiogenesis, mechanism, overview | Mus musculus C3H/HEN | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Mus musculus |
HO-1 | - |
Mus musculus |