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Literature summary for 1.14.14.18 extracted from
- Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2-production in a two-hit model of alcohol intoxication and burn injury (2008), J. Immunol., 180, 6933-6940.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cobalt protoporphyrin IX chloride | Copp, a HO-1 activator | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | EtOH combined with burn injury significantly increases neutrophil O2- production and p47phox and p67phox activation and decreases caspase-3 activity and apoptosis, accompanied with a decrease in neutrophil HO-1 levels, overview | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | Rattus norvegicus | HO-1 acts as anti-oxidant and protects cells against injury, it regulates neutrophil O2- production and protects the intestine from damage following EtOH and burn injury, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | P06762 | male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neutrophil | neutrophil HO-1 expression is similar in rats receiving burn injury alone compared with shams gavaged with saline, however, as compared with rats receiving EtOH intoxication, neutrophil HO-1 expression in burn rats is significantly decreased. Furthermore, a significant decrease in neutrophil HO-1 expression is observed in rats receiving a combined insult of EtOH intoxication and burn injury compared with rats receiving either sham or burn injury alone | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| heme + AH2 + O2 | - |
Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
| heme + AH2 + O2 | HO-1 acts as anti-oxidant and protects cells against injury, it regulates neutrophil O2- production and protects the intestine from damage following EtOH and burn injury, overview | Rattus norvegicus | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heme oxygenase-1 | - |
Rattus norvegicus |
| HO-1 | - |
Rattus norvegicus |
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