Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | oxidized-1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, i.e. Ox-PAPC, induces HO-1 involving Nrf2 activation, the transcriptional activation is regulated by the plasma membrane electron transport complex, PMET, containing ecto-NADH oxidase 1, eNOX1, and NADPH:quinone oxidoreductase 1, NQO1. Chemical inhibitors of PMET system and siRNAs to PMET components NQO1 and eNOX1, as well as exogenous NAD(P)H significantly decrease HO-1 induction by Ox-PAPC | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | Homo sapiens | HO-1 is a cell-protective anti-oxidant enzyme, which is sensitively induced by oxidative stress and regulated by oxidized-1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, i.e. Ox-PAPC, and Nrf2, overview | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09601 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
endothelial cell | aortic endothelial cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + AH2 + O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? | |
heme + AH2 + O2 | HO-1 is a cell-protective anti-oxidant enzyme, which is sensitively induced by oxidative stress and regulated by oxidized-1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, i.e. Ox-PAPC, and Nrf2, overview | Homo sapiens | biliverdin + Fe2+ + CO + A + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |