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Literature summary for 1.14.14.18 extracted from

  • Park, C.; Cho, I.H.; Kim, D.; Jo, E.K.; Choi, S.Y.; Oh, S.B.; Park, K.; Kim, J.S.; Lee, S.J.
    Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury (2008), Neurosci. Lett., 431, 123-128.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the toll-like receptor 2 is involved in HO-1 induction in glial cells, 34fold induction of HO-1 by stab-wound injury in wild-type mice, overview Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information HO-1 expression is reduced in toll-like receptor 2 TLR2-knockout mice after stab-wound injury, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + AH2 + O2 Mus musculus HO-1 gene is a glia-expressing wound-responsive gene, HO-1 gene expression associated with traumatic brain injury involving the toll-like receptor 2, overview biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 Mus musculus C57BL/6 HO-1 gene is a glia-expressing wound-responsive gene, HO-1 gene expression associated with traumatic brain injury involving the toll-like receptor 2, overview biliverdin + Fe2+ + CO + A + H2O
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus P14901 C57BL/6 mice
-
Mus musculus C57BL/6 P14901 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
glial cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + AH2 + O2
-
Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 gene is a glia-expressing wound-responsive gene, HO-1 gene expression associated with traumatic brain injury involving the toll-like receptor 2, overview Mus musculus biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2
-
Mus musculus C57BL/6 biliverdin + Fe2+ + CO + A + H2O
-
?
heme + AH2 + O2 HO-1 gene is a glia-expressing wound-responsive gene, HO-1 gene expression associated with traumatic brain injury involving the toll-like receptor 2, overview Mus musculus C57BL/6 biliverdin + Fe2+ + CO + A + H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-1
-
Mus musculus
HO-1
-
Mus musculus