Application | Comment | Organism |
---|---|---|
medicine | reduction in HO activity may contribute to the protective effect of MEK and ERK inhibitors against heme-mediated neuronal injury | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FR180204 | ERK inhibitor, reduces baseline culture HO activity, without altering the activity of recombinant HO-1 or HO-2 | Mus musculus | |
SL327 | MEK inhibitor, reduces baseline culture HO activity, without altering the activity of recombinant HO-1 or HO-2 | Mus musculus | |
U0126 | MEK inhibitor, reduces baseline culture HO activity, without altering the activity of recombinant HO-1 or HO-2 | Mus musculus | |
zinc protoporphyrin IX | activity of both recombinant isoenzymes HO-1 and HO-2 is strongly inhibited | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
fetal B6129 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glial cell line | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase | - |
Mus musculus |
HO-1 | - |
Mus musculus |
HO-2 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | HO-1 induction after hemoglobin treatment is decreased by about half by MEK inhibitors U0126 and SL327, and is completely prevented by the direct ERK inhibitor FR180204 | down |
Mus musculus | HO-1 induction by hemoglobin. In cultures treated with hemoglobin plus dimethylsulfoxide vehicle for 4 h, which is a time point prior to the onset of neuronal lysis, HO-1 expression is increased 2.2fold over control cultures treated with vehicle only | up |