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Literature summary for 1.14.14.18 extracted from
- Heme oxygenase-1 signals are involved in preferential inhibition of pro-inflammatory cytokine release by surfactin in cells activated with Porphyromonas gingivalis lipopolysaccharide (2010), Chem. Biol. Interact., 188, 437-445.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mouth | oral tissue | Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| heme oxygenase-1 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | small interfering RNA-mediated knock-down of Nrf-2 significantly inhibits surfactin-induced HO-1 expression. Inhibition of phosphoinositide 3-kinase/Akt and extracellular signal-regulated kinase significantly decreased surfactin-induced HO-1 expression, mechanism of surfactin, overview | down |
| Homo sapiens | surfactin, a cyclic lipopeptide produced by Bacillus subtilis, induces HO-1 mRNA and protein expression via activation of Nrf2, and PI3K/Akt and ERK, mechanism of surfactin, overview. Nrf-2 is a redox-sensitive basic-leucine zipper transcription factor | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | heme oxygenase-1 signals are involved in preferential inhibition of pro-inflammatory cytokine release by surfactin, produced by Bacillus subtilis, in cells activated with Porphyromonas gingivalis lipopolysaccharide | Homo sapiens |
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