Cloned (Comment) | Organism |
---|---|
adenovirus-mediated HO-1 transfection of Rattus norvegicus primary cardiomyocytes and H9C2 myocytes | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | adenovirus-mediated HO-1 transduction of Rattus norvegicus primary cardiomyocytes and H9C2 myocytes results in significant induction of VEGF expression, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-1 | - |
Homo sapiens |
HO-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | heme oxygenase-1/CO induces vascular endothelial growth factor expression via p38 kinase-dependent activation of Sp1. CO-induced VEGF promoter activation requires the binding of the Sp1 transcriptional factor to a cis-regulatory sequence located at the VEGF promoter. HO-1/CO induced p38-dependent phosphorylation of Sp1 at Thr453 and Thr739 both in vitro and in vivo | Homo sapiens |