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Literature summary for 1.14.14.18 extracted from

  • Gardner, J.D.; Yi, L.; Ragsdale, S.W.; Brunold, T.C.
    Spectroscopic insights into axial ligation and active-site H-bonding in substrate-bound human heme oxygenase-2 (2010), J. Biol. Inorg. Chem., 15, 1117-1127.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
C127A site-directed mutagenesis of the truncated HO-2 variant lacking the membrane spanning domain, spectral properties in comparison to the wild-type HO-2, overview Homo sapiens
C127A/C282A site-directed mutagenesis of the truncated HO-2 variant lacking the membrane spanning domain, spectral properties in comparison to the wild-type HO-2, overview Homo sapiens
additional information construction of a truncated HO-2 variant lacking the membrane spanning domain, spectral properties in comparison to the wild-type HO-2, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
heme + 3 AH2 + 3 O2 Homo sapiens
-
biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoforms HO-1 and HO-2
-

Source Tissue

Source Tissue Comment Organism Textmining
brain HO-2 Homo sapiens
-
liver HO-1 Homo sapiens
-
spleen HO-1 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
heme + 3 AH2 + 3 O2
-
Homo sapiens biliverdin + Fe2+ + CO + 3 A + 3 H2O
-
?

Synonyms

Synonyms Comment Organism
heme oxygenase-2
-
Homo sapiens
HO-2
-
Homo sapiens

General Information

General Information Comment Organism
additional information regulation of isozyme HO-2, overview. Presence of three Cys residues as part of heme-regulatory motifs in HO-2, low-spin Fe(III) heme species are characteristic of thiolate ligation is formed when Cys265 is reduced. Resonance Raman data collected at different temperatures reveal an intriguing temperature dependence of the iron spin state in the heme-HO-2 complex Homo sapiens
physiological function by catalyzing the first step in heme degradation, heme oxygenase plays a vital role in maintaining proper heme homeostasis. Isozymes HO-1 and HO-2, exist that catalyze the same reaction but differ in several notable ways, overview Homo sapiens