Protein Variants | Comment | Organism |
---|---|---|
C127A | site-directed mutagenesis of the truncated HO-2 variant lacking the membrane spanning domain, spectral properties in comparison to the wild-type HO-2, overview | Homo sapiens |
C127A/C282A | site-directed mutagenesis of the truncated HO-2 variant lacking the membrane spanning domain, spectral properties in comparison to the wild-type HO-2, overview | Homo sapiens |
additional information | construction of a truncated HO-2 variant lacking the membrane spanning domain, spectral properties in comparison to the wild-type HO-2, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + 3 AH2 + 3 O2 | Homo sapiens | - |
biliverdin + Fe2+ + CO + 3 A + 3 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoforms HO-1 and HO-2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | HO-2 | Homo sapiens | - |
liver | HO-1 | Homo sapiens | - |
spleen | HO-1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
heme + 3 AH2 + 3 O2 | - |
Homo sapiens | biliverdin + Fe2+ + CO + 3 A + 3 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
heme oxygenase-2 | - |
Homo sapiens |
HO-2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | regulation of isozyme HO-2, overview. Presence of three Cys residues as part of heme-regulatory motifs in HO-2, low-spin Fe(III) heme species are characteristic of thiolate ligation is formed when Cys265 is reduced. Resonance Raman data collected at different temperatures reveal an intriguing temperature dependence of the iron spin state in the heme-HO-2 complex | Homo sapiens |
physiological function | by catalyzing the first step in heme degradation, heme oxygenase plays a vital role in maintaining proper heme homeostasis. Isozymes HO-1 and HO-2, exist that catalyze the same reaction but differ in several notable ways, overview | Homo sapiens |