Application | Comment | Organism |
---|---|---|
medicine | the vital role of CYP17 in androgen biosynthesis makes it a potential molecular target for gene therapetutic strategy | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene CYP17, expression in HeLa cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of CYP17 by siRNA in HeLa cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | siRNA targeting the CYP17 gene | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | Homo sapiens | 17,20-lyase activity | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | 17,20-lyase activity | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | - |
gene CYP17 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
ovarian follicle | - |
Homo sapiens | - |
theca cell | polycystic ovary syndrome, PCOS, theca cell | Homo sapiens | - |
theca cell | androgen-secreting, from females with polycystic ovary syndrome undergoing hysterectomy or ovarian wedge resection | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
pregnenolone + AH2 + O2 | 17,20-lyase activity | Homo sapiens | 17alpha-hydroxypregnenolone + A + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | 17,20-lyase activity | Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17alpha-hydroxylase/17,20-lyase | - |
Homo sapiens |
CYP17 | - |
Homo sapiens |
cytochrome P450 17alpha-hydroxylase/17,20-lyase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | RNAi effectively reduces the expression of exogenous CYP17 in HeLa cells by up to 50%. The CYP17 mRNA and androstenedione production of theca cells are slightly, but not significantly, reduced when compared with non-specific siRNA | down |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is important in adrogene biosynthesis | Homo sapiens |