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Literature summary for 1.14.14.19 extracted from

  • Du, J.; Liang, X.; Zeng, H.; Shu, Y.; Yao, S.; Zhu, B.; Zhuang, G.
    Effect of small interfering RNAs of cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) on androgen biosynthesis in theca cells (2008), Cell Biol. Int., 32, 469-472.
    View publication on PubMed

Application

Application Comment Organism
medicine the vital role of CYP17 in androgen biosynthesis makes it a potential molecular target for gene therapetutic strategy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP17, expression in HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information downregulation of CYP17 by siRNA in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNA siRNA targeting the CYP17 gene Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pregnenolone + AH2 + O2 Homo sapiens 17,20-lyase activity 17alpha-hydroxypregnenolone + A + H2O
-
?
progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens 17,20-lyase activity 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens
-
gene CYP17
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
ovarian follicle
-
Homo sapiens
-
theca cell polycystic ovary syndrome, PCOS, theca cell Homo sapiens
-
theca cell androgen-secreting, from females with polycystic ovary syndrome undergoing hysterectomy or ovarian wedge resection Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pregnenolone + AH2 + O2 17,20-lyase activity Homo sapiens 17alpha-hydroxypregnenolone + A + H2O
-
?
progesterone + [reduced NADPH-hemoprotein reductase] + O2 17,20-lyase activity Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

Synonyms Comment Organism
17alpha-hydroxylase/17,20-lyase
-
Homo sapiens
CYP17
-
Homo sapiens
cytochrome P450 17alpha-hydroxylase/17,20-lyase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens RNAi effectively reduces the expression of exogenous CYP17 in HeLa cells by up to 50%. The CYP17 mRNA and androstenedione production of theca cells are slightly, but not significantly, reduced when compared with non-specific siRNA down

General Information

General Information Comment Organism
metabolism the enzyme is important in adrogene biosynthesis Homo sapiens