Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli JM109 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R347K | the mutant exhibits similar 17-hydroxylase and b5-stimulated 17,20-lyase activity as the wild type enzyme | Homo sapiens |
R358K | the mutant exhibits similar 17-hydroxylase and b5-stimulated 17,20-lyase activity as the wild type enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme also shows 17,20-lyase activity which is stimulated by cytochrome b5 | ? | - |
? | |
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | Homo sapiens | - |
17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P05093 | - |
- |
Purification (Comment) | Organism |
---|---|
nickel-nitrilotriacetic acid affinity resin column chromatography, His Select resin column chromatography, and Sartorius Vivapure-S spin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme also shows 17,20-lyase activity which is stimulated by cytochrome b5 | Homo sapiens | ? | - |
? | |
pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
progesterone + [reduced NADPH-hemoprotein reductase] + O2 | - |
Homo sapiens | 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP17A1 | - |
Homo sapiens |
cytochrome P450c17 | - |
Homo sapiens |