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Literature summary for 1.14.14.23 extracted from

  • Tiemann, M.; Han, Z.; Soccio, R.; Bollineni, J.; Shefer, S.; Sehayek, E.; Breslow, J.L.
    Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity (2004), Proc. Natl. Acad. Sci. USA, 101, 1846-1851.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.14.23

Cloned(Commentary)

Cloned (Comment) Organism
recombinant enzyme expressed in transgenic mice Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Mus musculus first step of cholesterol catabolism, rate-limiting enzyme in the classical pathway of bile acid synthesis 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens first step of cholesterol catabolism, rate-limiting enzyme in the classical pathway of bile acid synthesis 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 knockout and heterozygous mice
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Mus musculus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 first step of cholesterol catabolism, rate-limiting enzyme in the classical pathway of bile acid synthesis Mus musculus 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 first step of cholesterol catabolism, rate-limiting enzyme in the classical pathway of bile acid synthesis Homo sapiens 7alpha-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Homo sapiens