Literature summary for 1.14.14.24 extracted from

De Toni, L.; De Filippis, V.; Tescari, S.; Ferigo, M.; Ferlin, A.; Scattolini, V.; Avogaro, A.; Vettor, R.; Foresta, C.
Uncarboxylated osteocalcin stimulates 25-hydroxy vitamin D production in Leydig cell line through a GPRC6a-dependent pathway (2014), Endocrinology, 155, 4266-4274.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q6VVW9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Leydig cell	-	Mus musculus	-
MA-10 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
CYP2R1	-	Mus musculus
vitamin D 25-hydroxylase	-	Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	the luteinizing hormone induces the enzyme. MA-10 cell stimulation with either human chorionic gonadotropin or uncarboxylated-osteocalcin increases CYP2R1 protein expression in a dose-dependent manner and, in turn, increases the release of 25-hydroxy-vitamin D in culture medium. Osteocalcin, in particular uncarboxylated osteocalcin, stimulates 25-hydroxylation of vitamin D in Leydig cells through a direct effect on the expression of the main actor in the 25-hydroxylase activity of vitamin D, the CYP2R1 protein	up

General Information

General Information	Comment	Organism
metabolism	the cross talk from the bone to the testis of the vitamin D 25-hydroxylase CYP2R1 involves osteocalcin, which is produced by the osteoblasts and stimulates the production of testosterone by the Leydig cells through its putative receptor GPRC6A, a cation-sensing G-protein-coupled receptor. Action of osteocalcin on CYP2R1 expression and 25-hydroxyvitamin D production in a mouse Leydig cell line MA-10	Mus musculus

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Release 2023.1 (January 2023)