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Literature summary for 1.14.14.25 extracted from
- Oxysterol biosynthetic enzymes (2000), Biochim. Biophys. Acta, 1529, 126-135.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56821 | - |
x * 56821, calculation from nucleotide sequence | Homo sapiens |
| 56821 | - |
x * 56821, calculation from nucleotide sequence | Mus musculus |
| 56842 | - |
x * 56842 | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | Homo sapiens | 24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
| cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | Mus musculus | 24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y6A2 | - |
- |
| Mus musculus | Q9WVK8 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Homo sapiens | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | - |
Mus musculus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | 24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain | Homo sapiens | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
| cholesterol + [reduced NADPH-hemoprotein reductase] + H+ + O2 | 24-hydroxylation represents an important pathway by which cholesterol is secreted from the brain. The enzyme contributes little to overall bile acid synthesis but is important in the turnover of cholesterol in the brain | Mus musculus | (24S)-24-hydroxycholesterol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 56821, calculation from nucleotide sequence | Homo sapiens |
| ? | x * 56821, calculation from nucleotide sequence | Mus musculus |
| ? | x * 56842 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP46 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P-450 | - |
Homo sapiens | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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