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Literature summary for 1.14.14.25 extracted from

  • He, X.; Jenner, A.M.; Ong, W.Y.; Farooqui, A.A.; Patel, S.C.
    Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury (2006), J. Neuropathol. Exp. Neurol., 65, 652-663.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
lovastatin induces and activates the enzyme, acts neuroprotectively in hippocampus after kainate injury, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + reduced adrenodoxin + O2 Rattus norvegicus
-
 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus after kainate lesions Rattus norvegicus
-
neuron hippocampal Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + reduced adrenodoxin + O2
-
 Rattus norvegicus 24-hydroxycholesterol + oxidized adrenodoxin + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus