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Literature summary for 1.14.14.25 extracted from

  • Koelsch, H.; Luetjohann, D.; Jessen, F.; Popp, J.; Hentschel, F.; Kelemen, P.; Schmitz, S.; Maier, W.; Heun, R.
    CYP46A1 variants influence Alzheimers disease risk and brain cholesterol metabolism (2009), Eur. Psychiatry, 24, 183-190.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
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Homo sapiens
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Synonyms

Synonyms Comment Organism
CYP46A1
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Homo sapiens
cytochrome P450 cholesterol 24-hydroxylase
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Homo sapiens

General Information

General Information Comment Organism
metabolism CYP46A1 gene variations (rs7157609 and rs4900442) influence the risk factor for Alzheimer's disease via an influence on brain cholesterol metabolism, especially the interaction term of both SNPs and the resulting haplotype reveal a strong association with the risk of Alzheimer’s disease Homo sapiens