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Literature summary for 1.14.14.25 extracted from

  • Fourgeux, C.; Martine, L.; Acar, N.; Bron, A.M.; Creuzot-Garcher, C.P.; Bretillon, L.
    In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina (2014), Biochem. Biophys. Res. Commun., 446, 775-781.
    View publication on PubMed
Search for more literature for 1.14.14.25

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP46A1, quantitative expression analysis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
voriconazole voriconazole decreases 24S-hydroxycholesterol levels in the retina. CYP46A1 expression is increased in the retina of voriconazole-treated rats. Intercellular adhesion molecule 1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1) show significant increases in the retina and vitreous body. Minocycline did not reverse the effects of voriconazole Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus
-
 (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 Rattus norvegicus Wistar
-
 (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus F7EN52 gene CYP46A1
-
Rattus norvegicus Wistar F7EN52 gene CYP46A1
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
central nervous system
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-
retina
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
cholesterol + [reduced NADPH-hemoprotein reductase] + O2
-
 Rattus norvegicus Wistar (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cholesterol 24S-hydroxylase
-
 Rattus norvegicus
cholesterol-24S-hydroxylase
-
 Rattus norvegicus
CYP46A1
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus CYP46A1 expression is increased in the retina of voriconazole-treated rats up

General Information

General Information Comment Organism
physiological function cholesterol 24S-hydroxylase converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina Rattus norvegicus