Any feedback?
Literature summary for 1.14.14.29 extracted from
- The enzymes, regulation, and genetics of bile acid synthesis (2003), Annu. Rev. Biochem., 72, 137-174.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Mus musculus | 5783 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58255 | - |
x * 58255, calculation from nucleotide sequence | Homo sapiens |
| 58255 | - |
x * 58255, calculation from nucleotide sequence | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | Mus musculus | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? |  |
| cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | Mus musculus | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O75881 | - |
- |
| Mus musculus | Q60991 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | hepatic expression is induced during the third week of life and thereafter exhibits a sexually dimorphic expression pattern in this and other tissues in which expression is higher in the male | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | - |
Homo sapiens | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | - |
Mus musculus | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | Mus musculus | cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O | - |
? | |
| cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | - |
Homo sapiens | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
| cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | - |
Mus musculus | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
| cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 | CYP7B1 oxysterol 7alpha-hydroxylase pathway synthesizes 25% to 30% of all bile acids | Mus musculus | cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 58255, calculation from nucleotide sequence | Homo sapiens |
| ? | x * 58255, calculation from nucleotide sequence | Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cytochrome P-450 | - |
Homo sapiens | |
| cytochrome P-450 | - |
Mus musculus | |
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
