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Literature summary for 1.14.15.15 extracted from

  • Okuda, K.; Ruf, H.H.; Ullrich, V.
    Spectral evidence for a liver mitochondrial cytochrome P450 involved in bile acid metabolism (1977), Hoppe-Seyler's Z. Physiol. Chem., 358, 689-694.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 Rattus norvegicus mitochondrial cytochrome P450 forms a complex with the substrate ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2
-
Rattus norvegicus 5beta-cholestane-3alpha,7alpha,12alpha,27-tetrol + oxidized adrenodoxin + H2O
-
?
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 mitochondrial cytochrome P450 forms a complex with the substrate Rattus norvegicus ?
-
?

Cofactor

Cofactor Comment Organism Structure
cytochrome P450 mitochondrial cytochrome-P450 forms an enzyme-substrate complex with 5beta-cholestane-3alpha,7alpha,12alpha-triol with Km value very similar to the Km value of 26-hydroxylation Rattus norvegicus