Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determinationa nd analysis, functional expression in COS-M6 cells, overview | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Oryctolagus cuniculus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
56657 | - |
x * 56657, amino acid sequence calculation | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2 | Oryctolagus cuniculus | - |
5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O | - |
? | |
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 | Oryctolagus cuniculus | - |
5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O | - |
? | |
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 | Oryctolagus cuniculus | - |
5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O | - |
? | |
7alpha-hydroxy-4-cholesten-3-one + reduced adrenodoxin + O2 | Oryctolagus cuniculus | - |
7alpha,26-dihydroxy-4-cholesten-3-one + oxidized adrenodoxin + H2O | - |
? | |
cholesterol + reduced adrenodoxin + H+ + O2 | Oryctolagus cuniculus | - |
26-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? | |
additional information | Oryctolagus cuniculus | the enzyme catalyzes the first step in the oxidation of the side chain of sterol intermediates in the biosynthesis of bile acids | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme partially by mitochondria preparation | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-cholestene-3beta,7alpha-diol + reduced adrenodoxin + O2 | - |
Oryctolagus cuniculus | 5-cholestene-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O | - |
? | |
5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + O2 | - |
Oryctolagus cuniculus | 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O | - |
? | |
5beta-cholestane-3alpha,7alpha-diol + reduced adrenodoxin + O2 | - |
Oryctolagus cuniculus | 5beta-cholestane-3alpha,7alpha,26-triol + oxidized adrenodoxin + H2O | - |
? | |
7alpha-hydroxy-4-cholesten-3-one + reduced adrenodoxin + O2 | - |
Oryctolagus cuniculus | 7alpha,26-dihydroxy-4-cholesten-3-one + oxidized adrenodoxin + H2O | - |
? | |
cholesterol + reduced adrenodoxin + H+ + O2 | - |
Oryctolagus cuniculus | 26-hydroxycholesterol + oxidized adrenodoxin + H2O | - |
? | |
additional information | the enzyme catalyzes the first step in the oxidation of the side chain of sterol intermediates in the biosynthesis of bile acids | Oryctolagus cuniculus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 56657, amino acid sequence calculation | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
cytochrome P-450 sterol 26-hydroxylase | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Ferredoxin | - |
Oryctolagus cuniculus | |
NADPH | - |
Oryctolagus cuniculus |