Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | endogenous and pharmacological glucocorticoids may have a strong impact on several aspects of cholesterol homeostasis and other processes related to CYP27A1-mediated metabolism | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
CYP27A1 | - |
Homo sapiens |
sterol 27-hydroxylase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | dexamethasone increases CYP27A1-mediated enzyme activity in HepG2 cells by CYP27A1 promoter activity more than 4fold as compared with untreated cells, mediated by glucocorticoid receptor alpha, glucocorticoid receptor alpha-antagonist mifepristone almost completely abolishes the dexamethasone-induced effect on the CYP27A1 promoter activity | up |