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Literature summary for 1.14.15.15 extracted from
- Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling (2009), Neuroscience, 164, 530-540.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | astrocyte-restricted upregulation of Cyp27a1 due to to differential expression of transcriptional co-activators, increase of enzyme mRNA and protein levels in treated astrocytes is paralleled by transactivation of the proximal Cyp27a1 promoter in transfected astrocytes | Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| CYP27 expression analysis in the brain | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + H+ + O2 | Rattus norvegicus | - |
(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O | - |
? |  |
| additional information | Rattus norvegicus | sterol 27-hydroxylase is regulated by liver X receptor signaling, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | primary astrocytes express different sterol hydroxylases and are able to uptake exogenous 27-hydroxycholesterol | Rattus norvegicus | - |
| brain | Cyp27a1 is expressed in all the cell types but at highest levels in microglia | Rattus norvegicus | - |
| central nervous system | expression pattern of Cyp27a1 and other related genes in primary cultures of glia and neurons | Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| microglia | - |
Rattus norvegicus | - |
| neuron | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced adrenodoxin + H+ + O2 | - |
Rattus norvegicus | (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + oxidized adrenodoxin + H2O | - |
? | |
| additional information | sterol 27-hydroxylase is regulated by liver X receptor signaling, overview | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CYP27 | - |
Rattus norvegicus |
| sterol 27-hydroxylase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | astrocyte-restricted upregulation of Cyp27a1 due to to differential expression of transcriptional co-activators, increase of enzyme mRNA and protein levels in treated astrocytes is paralleled by transactivation of the proximal Cyp27a1 promoter in transfected astrocytes | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme deficiency causes a disease characterized by progressive neurologic impairment. Impairment of CYP27 activity in astrocytes may alter critical features of the astrocytes, from the handling and delivery of cholesterol to neurons to the release of signaling molecules | Rattus norvegicus |
| metabolism | the enzyme is involved in cholesterol handling and metabolism | Rattus norvegicus |
| physiological function | pathophysiological role of CYP27A1 in the CNS | Rattus norvegicus |
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Release 2023.1 (January 2023)
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