Literature summary for 1.14.15.15 extracted from

Endo-Umeda, K.; Yasuda, K.; Sugita, K.; Honda, A.; Ohta, M.; Ishikawa, M.; Hashimoto, Y.; Sakaki, T.; Makishima, M.
7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity (2013), J. Steroid Biochem. Mol. Biol., 140, 7-16.

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Application

Application	Comment	Organism
medicine	7-dehydrocholesterol is catabolized by isoform CYP27A1 to metabolites that act as selective liver X receptor LXR modulators. Metabolites detected in serum of a patient with Smith-Lemli-Opitz syndrome are 25-hydroxy-7-dehydrocholesterol which activates liver X receptors LXRalpha, LXRbeta and vitamin D receptor and 26/27-hydroxy-7-dehydrocholesterol which induces activation of LXRalpha and LXRbeta, although the activities of both compounds on LXRs are weak	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-dehydrocholesterol + 4 reduced adrenodoxin + 2 H+ + 2 O2	-	Homo sapiens	25-hydroxy-7-dehydrocholesterol + 26/27-hydroxy-7-dehydrocholesterol + 4 oxidzed adrenodoxin + 2 H2O	metabolites detected in serum of a patient with Smith-Lemli-Opitz syndrome. 25-hydroxy-7-dehydrocholesterol activates liver X receptors LXRalpha, LXRbeta and vitamin D receptor and 26/27-hydroxy-7-dehydrocholesterol induces activation of LXRalpha and LXRbeta, although the activities of both compounds on LXRs are weak. 26/27-Hydroxy-7-dehydrocholesterol is (3S,25S)-cholesta-5,7-diene-3,26-diol or (3S,25R)-cholesta-5,7-diene-3,26-diol	?

Synonyms

Synonyms	Comment	Organism
CYP27A1	-	Homo sapiens

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Release 2023.1 (January 2023)