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Literature summary for 1.14.15.16 extracted from
- Mouse vitamin D-24-hydroxylase: molecular cloning, tissue distribution, and transcriptional regulation by 1alpha,25-dihydroxyvitamin D3 (1997), Endocrinology, 138, 2233-2240.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55450 | - |
mature enzyme, calculated from amino acid sequence | Mus musculus |
| 59500 | - |
calculated from amino acid sequence | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | - |
Mus musculus | - |
| colon | - |
Mus musculus | - |
| duodenum | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| ileum | - |
Mus musculus | - |
| intestine | highest mRNA expression | Mus musculus | - |
| jejunum | - |
Mus musculus | - |
| kidney | highest mRNA expression | Mus musculus | - |
| lung | - |
Mus musculus | - |
| pancreas | - |
Mus musculus | - |
| skin | - |
Mus musculus | - |
| spleen | - |
Mus musculus | - |
| testis | - |
Mus musculus | - |
| thymus | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2 | - |
Mus musculus | 1alpha,24R,25-trihydroxyvitamin D3 + NADP+ + H2O | - |
? |  |
| 25-hydroxyvitamin D3 + NADPH + H+ + O2 | - |
Mus musculus | 24R,25-dihydroxyvitamin D3 + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 24-OHase | - |
Mus musculus |
| vitamin D-24-hydroxylase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Mus musculus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mus musculus | intraperitoneal injection of 1,25-dihydroxyvitamin D3 induces dose- and time-dependent increases in both 24-OHase mRNA abundance and enzyme activity in mouse kidney reaching a maximum between 4-8 h, after which it decreases and then maintains a steady value between 18-72 h. Similarly, 1,25-dihydroxyvitamin D3-induced increases in both 24-OHase mRNA and activity are apparent in the duodenum. Although 1,25-dihydroxyvitamin D3 markedly the amount of 24-OHase mRNA in skin between 4 and 6 h, enzyme activity is not detected in this tissue. Pretreatment of mice with cycloheximide (0.4mg/g) potentiates the increase in 24-OHase mRNA abundance but blocks the increase in 24-OHase activity, induced by 1,25-dihydroxyvitamin D3 in kidney and duodenum | up |
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