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Literature summary for 1.14.15.16 extracted from

  • Urbschat, A.; Paulus, P.; von Quernheim, Q.F.; Brueck, P.; Badenhoop, K.; Zeuzem, S.; Ramos-Lopez, E.
    Vitamin D hydroxylases CYP2R1, CYP27B1 and CYP24A1 in renal cell carcinoma (2013), Eur. J. Clin. Invest., 43, 1282-1290.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
calcidiol + NADPH + H+ + O2 Homo sapiens
-
secalciferol + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
renal cell carcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
calcidiol + NADPH + H+ + O2
-
Homo sapiens secalciferol + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
CYP24A1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is upregulated in tumor cells compared with normal tissue up

General Information

General Information Comment Organism
physiological function upregulated gene expression of CYP24A1 leads to a misbalance of vitamin D metabolites in clear cell renal cell carcinomas and thus contributing to its pathogenesis Homo sapiens