Any feedback?
Literature summary for 1.14.15.18 extracted from
- Studies on calciferol metabolism. IX. Renal 25-hydroxy-vitamin D3-1 hydroxylase. Involvement of cytochrome P-450 and other properties (1974), J. Biol. Chem., 249, 7529-7535.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CN- | activates with malate as electron donor | Gallus gallus |  |
| malate | supports 1alpha-hydroxylation as electron donor | Gallus gallus | |
| succinate | supports 1alpha-hydroxylation as electron donor | Gallus gallus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| antimycin A | higher inhibition rate with succinate as electron donor than with malate | Gallus gallus | |
| Ca2+ | - |
Gallus gallus | |
| dinitrophenol | higher inhibition rate with malate as electron donor than with succinate | Gallus gallus | |
| Mn2+ | - |
Gallus gallus | |
| additional information | no inhibition with Ba2+, acetate, sulfate | Gallus gallus | |
| phosphate | - |
Gallus gallus | |
| Sr2+ | - |
Gallus gallus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Gallus gallus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Gallus gallus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxycholecalciferol + NADPH + O2 | Gallus gallus | - |
calcitriol + NADP+ + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 25-hydroxycholecalciferol + NADPH + O2 | - |
Gallus gallus | calcitriol + NADP+ + H2O | - |
? | |
| calcidiol + NADPH + O2 | highly specific for calcidiol, calcidiol is identical with 25-hydroxycholecalciferol | Gallus gallus | calcitriol + NADP+ + H2O | calcitriol is identical with 1,25-dihydroxycholecalciferol | ? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Gallus gallus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
