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Literature summary for 1.14.15.18 extracted from

  • Segersten, U.; Holm, P.K.; Björklund, P.; Hessman, O.; Nordgren, H.; Binderup, L.; Akerström, G.; Hellman, P.; Westin, G.
    25-Hydroxyvitamin D3 1alpha-hydroxylase expression in breast cancer and use of non-1alpha-hydroxylated vitamin D analogue (2005), Breast Cancer Res., 7, R980-R986.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.15.18

Activating Compound

Activating Compound Comment Organism Structure
additional information EB1285, a non-1alpha-hydroxylated vitamin D analogue prodrug of EB1089, shows about 20% ketoconazole-sensitive transcription activation of the enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2 Homo sapiens the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15528
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
breast cancer cell the enzyme expression is reduced in breast cancer cell specimen compared to healthy breast tissue Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
parathyroid gland enzyme expression in secondary hyperparathyroidism Homo sapiens
-
renal tubule
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
25-hydroxyvitamin D + NADPH + O2
-
 Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?
25-hydroxyvitamin D + NADPH + O2 the enzyme hydroxylates the major circulating form of vitamin D to the active systemic hormone 1,25(OH)2D3, local production of 1,25(OH)2D3 appears to occur also at other sites where 1alpha-hydroxylase is expressed for autocrine/paracrine regulation, overview Homo sapiens 1alpha,25-dihydroxyvitamin D + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
1alpha-hydroxylase
-
 Homo sapiens
25-hydroxyvitamin D3 1alpha-hydroxylase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens