Literature summary for 1.14.15.3 extracted from

Helvig, C.; Alayrac, C.; Mioskowski, C.; Koop, D.; Poullain, D.; Durst, F.; Salaun, J.P.
Suicide inactivation of cytochrome P450 by midchain and terminal acetylenes. A mechanistic study of inactivation of a plant lauric acid omega-hydroxylase (1997), J. Biol. Chem., 272, 414-421.

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Inhibitors

Inhibitors	Comment	Organism	Structure
11-dodecynoic acid	completely inhibited lauric acid omega-hydroxylation	Oryctolagus cuniculus
11-dodecynoic acid	completely inhibited lauric acid omega-hydroxylation	Vicia sativa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microsome	-	Vicia sativa	-	-
microsome	-	Oryctolagus cuniculus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
n-alkane + NAD(P)H + H+ + O2	Vicia sativa	-	n-alkanol + NAD(P)+ + H2O	-	?
n-alkane + NAD(P)H + H+ + O2	Oryctolagus cuniculus	-	n-alkanol + NAD(P)+ + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	rabbit	-
Vicia sativa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
renal cortex	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
fatty acid + NAD(P)H + H+ + O2	-	Vicia sativa	omega-hydroxy fatty acid + NAD(P)+ + H2O	-	?
fatty acid + NAD(P)H + H+ + O2	-	Oryctolagus cuniculus	omega-hydroxy fatty acid + NAD(P)+ + H2O	-	?
lauric acid + NAD(P)H + H+ + O2	-	Vicia sativa	12-hydroxydodecanoic acid + NAD(P)+ + H2O	-	?
lauric acid + NAD(P)H + H+ + O2	-	Oryctolagus cuniculus	12-hydroxydodecanoic acid + NAD(P)+ + H2O	-	?
n-alkane + NAD(P)H + H+ + O2	-	Vicia sativa	n-alkanol + NAD(P)+ + H2O	-	?
n-alkane + NAD(P)H + H+ + O2	-	Oryctolagus cuniculus	n-alkanol + NAD(P)+ + H2O	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Vicia sativa
NADPH	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)