Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | in nonneuronal cells associated largely with sensory bristles | Drosophila melanogaster | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
Western blot analysis | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
antenna | second antennal segment, only males | Drosophila melanogaster | - |
eye | in the vibrissae, ventral outside edge of compound eyes, only males | Drosophila melanogaster | - |
head | at the base of machrochaetae, only males | Drosophila melanogaster | - |
additional information | SXE1 protein expression is restricted to nonneuronal cells associated with diverse sensory bristles of both the chemo- and mechanosensory systems. Is present in labial palps and tips of maxillary palps in males and females, and in the base of bristles of the forelegs and the base of arista of males | Drosophila melanogaster | - |
thorax | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fatty acid + NAD(P)H + H+ + O2 | - |
Drosophila melanogaster | omega-hydroxy fatty acid + NAD(P)+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP4d21 | - |
Drosophila melanogaster |
male-specific fatty acid omega-hydroxylase | - |
Drosophila melanogaster |
sex-specific enzyme 1 | - |
Drosophila melanogaster |
SXE1 | - |
Drosophila melanogaster |
Organism | Comment | Expression |
---|---|---|
Drosophila melanogaster | in the female labial palps, expression is weaker and restricted to a smaller area when compared to males | down |
Drosophila melanogaster | similar to sxe1 mRNA, expression of SXE1 protein in males oscillates in a diurnal fashion, with highest protein levels occurring around midnight | up |
General Information | Comment | Organism |
---|---|---|
malfunction | suppression or knockout of sxe1 significantly reduces mating success in males throughout the diurnal cycle | Drosophila melanogaster |
metabolism | the metabolomic profile of wild-type and sxe1 mutant males reveals that sxe1 likely functions as a fatty acid omega-hydroxylase, suggesting that male courtship and mating success is mediated by small compounds generated by this enzyme | Drosophila melanogaster |
physiological function | SXE1 is necessary for efficient male mating. Male-specific transcriptional regulator DSX(M) and the clock genes are necessary for cycling of sxe1 mRNA during the diurnal cycle | Drosophila melanogaster |