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Literature summary for 1.14.15.4 extracted from

  • Grant, J.K.; Brownie, A.C.
    The role of fumarate and TPN in steroid enzymic 11beta-hydroxylation (1955), Biochim. Biophys. Acta, 18, 433-434.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-oxoglutarate most potent activator in intact mitochondria Bos taurus
fumarate increase of activity Bos taurus
MnCl2 1 mM, reactivation of dialysed enzyme Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
EDTA 10 mM Bos taurus
KCN slight inhibitor Bos taurus
phosphate
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
ox
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-pregnen-21-ol-3,20-dione + reduced adrenal ferredoxin + O2 11-deoxycorticosterone, fumarate required in mitochondria treated with hypotonic solutions of electrolytes Bos taurus 4-pregnene-11,21-diol-3,20-dione + oxidized adrenal ferredoxin + H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH no reaction with NADH or NADP+ Bos taurus