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Literature summary for 1.14.15.4 extracted from

  • Ogishima, T.; Mitani, F.; Ishimura, Y.
    Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex (1989), J. Biol. Chem., 264, 10935-10938.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
49500
-
x * 49500 of capsular portion and x * 51500 of capsular and decapsular portion, 11beta-hydroxylase activities, SDS-PAGE Rattus norvegicus
51500
-
x * 49500 of capsular portion and x * 51500 of capsular and decapsular portion, 11beta-hydroxylase activities, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male, Sprague-Dawley, low sodium, high potassium treated
-

Purification (Commentary)

Purification (Comment) Organism
cholate extraction, hydroxyapatite HPLC Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex capsular portion in zona glomerulosa cells, decapsular in zonae fasciculata and reticularis Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
several activities of 49.5 and 51.5 kDa proteins for multihydroxylation steps Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2 49 kDa protein, exclusively in zona glomerulosa, 11beta -hydroxylation, as well as 18-hydroxylation and 18-hydroxydehydrogenation of corticosterone with 18-hydroxydeoxycorticosterone and 18-hydroxycorticosterone as intermediates Rattus norvegicus aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2 by 49.5 kDa protein from capsular portion, 11beta-/18-hydroxylation by 51.5 kDa protein Rattus norvegicus aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 by 49.5 kDa protein from capsular portion, 11beta-/18-hydroxylation by 51.5 kDa protein Rattus norvegicus corticosterone + oxidized adrenal ferredoxin + H2O
-
?
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 by 49.5 kDa protein from capsular portion, 11beta-/18-hydroxylation by 51.5 kDa protein Rattus norvegicus corticosterone + oxidized adrenal ferredoxin + H2O 51.5 kDa protein ?

Subunits

Subunits Comment Organism
? x * 49500 of capsular portion and x * 51500 of capsular and decapsular portion, 11beta-hydroxylase activities, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus