Inhibitors | Comment | Organism | Structure |
---|---|---|---|
iron-sulfur protein | adrenodoxin, at high concentrations, 25% inhibition | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Bos taurus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
sonication, acetone and butanol extraction, Triton extraction | Bos taurus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O | 2 step reduction: reduction of P-450 with non-specific donor and reduction which is specifically dependent on reduced iron-sulfur protein | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | 11beta-hydroxylation | Bos taurus | corticosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | less effective than NADPH | Bos taurus | |
NADPH | - |
Bos taurus |