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Literature summary for 1.14.15.4 extracted from

  • Yanigabashi, K.; Haniu, M.; Shively, J.E.; Shen, W.H.; Hall, P.
    The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11beta-, 18-hydroxylation, and aldehyde synthesis (1986), J. Biol. Chem., 261, 3556-3562.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Anti-11beta-hydroxylase IgG polyclonal, raised in rabbits, inhibition of 11-beta/18-hydroxylation and aldosterone synthesis of corticosterone Bos taurus
Metyrapone
-
Bos taurus
Metyrapone inhibition of the purified 11beta-hydroxylase, 18-hydroxylation and aldosterone synthesis of corticosterone are inhibited Sus scrofa
SKF 525A little inhibition of the purified 11beta-hydroxylase, 18-hydroxylation and aldosterone synthesis of corticosterone are inhibited Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion from zona fasciculata Bos taurus 5739
-
mitochondrion from zona glomerulosa Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
x * 46000, two-dimensional gel Sus scrofa
47500
-
x * 47500 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
copurification of 11beta-/18-hydroxylase, cholate extraction, ammonium sulfate precipitation, Tween extraction, octymine-Sepharose Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Sus scrofa
-
adrenal cortex
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00003
-
18-hydroxylation Bos taurus
0.0053
-
11beta-hydroxylation Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2
-
Bos taurus aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
?
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2 supported by adrenodoxin and adrenodoxin reductase, 3 step-hydroxylation with corticosterone and 18-hydroxycorticosterone as intermediates, 11beta-/18-hydroxylase Sus scrofa aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
?
corticosterone + reduced adrenal ferredoxin + O2 18-hydroxycorticosterone as intermediate of 11beta-hydroxylation Bos taurus aldosterone + oxidized adrenal ferredoxin + H2O
-
?

Subunits

Subunits Comment Organism
? x * 46000, two-dimensional gel Sus scrofa
? x * 47500 Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Sus scrofa
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Sus scrofa
NADPH
-
Bos taurus