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Literature summary for 1.14.15.4 extracted from

  • Ogishima, T.; Mitani, F.; Ishimura, Y
    Isolation of two distinct cytochromes P-45011beta with aldosterone synthase activity from bovine adrenocortical mitochondria (1989), J. Biochem., 105, 497-499.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion inner membrane, all 3 zones Bos taurus 5739
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Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Na-cholate extraction, ammonium sulfate precipitation, aniline-Sepharose chromatography, hydroxylapatite HPLC Bos taurus

Reaction

Reaction Comment Organism Reaction ID
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O 11beta-/18-hydroxylation and aldosterone synthesis are catalyzed by 2 distinct forms of cytochrome P-45011beta Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
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Bos taurus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2 11beta-hydroxylase and 18-hydroxylase activities, after replacement of Tween 20 by phosphatidylcholine catalytic activity for aldosterone activity is exhibited, form 1 higher active in aldosterone and 18-hydroxycorticosterone production and less active in the production of corticosterone and 18-hydroxydeoxycorticosterone from deoxycorticosterone as form 2 Bos taurus aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
?

Subunits

Subunits Comment Organism
? x * 48500-51500, SDS-PAGE after Sepharose, x * 48400/49500, SDS-PAGE after HPLC Bos taurus

Synonyms

Synonyms Comment Organism
cytochrome P-45011-beta
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Bos taurus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH adrenodoxin and NADPH-linked adrenodoxin reductase Bos taurus