Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.15.4 extracted from

  • Seybert, D.
    Lipid regulation of bovine cytochrome P45011beta activity (1990), Arch. Biochem. Biophys., 279, 188-194.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine saturated acyl chains such as dipalmitoyl/dimyristoyl phosphatidylcholine Bos taurus

General Stability

General Stability Organism
inclusion into phospholipid vesicles stabilizes Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
diphosphatidyl glycerol cardiolipin, dipalmitoyl phasphatidylcholine vesicles, 50% inhibition with 4-5 mol%, complete inhibition at 15 mol% Bos taurus
phosphatidylcholine unsaturated increasing dioleoyl/diphytanoyl phosphatidylcholine Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
11-deoxycorticosterone dipalmitoyl-phosphatidylcholine vesicles Bos taurus
0.01
-
11-deoxycorticosterone dipalmitoyl/diphytanoyl-phosphatidylcholine vesicles Bos taurus
0.033
-
11-deoxycorticosterone dipalmitoyl phosphatidylcholine/diphosphatidyl glycerol vesicles Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion from zona fasciculata Bos taurus 5739
-
mitochondrion reconstitution of cytochrome P45011beta, an intrinsic protein of inner membrane, into phospholipid vesicles via detergent dialysis procedure Bos taurus 5739
-
mitochondrion from zona reticularis Bos taurus 5739
-
mitochondrion from zona glomerulosa Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
without ionic detergents, ammonium sulfate fractionation, hexyl agarose Bos taurus

Reaction

Reaction Comment Organism Reaction ID
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O cytochrome P45011beta is implicated in mineralocorticoid, synthesized and secreted from zona glomerulosa, as well as glucocorticoid, secreted primarily in zonae fasciculate and reticularis, biosynthesis with multiple catalytic activities, 11beta-/18-/19-hydroxylase and 18-/19-hydroxysteroid oxidase activities Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
Bos taurus aldosterone + oxidized adrenal ferredoxin + H2O
-
?
19-hydroxy-11-deoxycorticosterone + reduced adrenal ferredoxin + O2
-
Bos taurus 19-oxo-11-deoxycorticosterone + oxidized adrenal ferredoxin + H2O
-
?
cortisol + reduced adrenal ferredoxin + O2
-
Bos taurus cortisone + oxidized adrenal ferredoxin + ?
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.133
-
11-deoxycorticosterone dipalmitoyl phosphatidylcholine vesicles + diphosphatidyl glycerol Bos taurus
0.583
-
11-deoxycorticosterone dipalmitoyl phosphatidylcholine vesicles Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADPH adrenodoxin and NADPH-linked adrenodoxin reductase Bos taurus