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BRENDA support

Literature summary for 1.14.15.4 extracted from

  • Yanigabashi, K.; Kobayashi, Y.; Hall, P.F.
    Ascorbate as a source of reducing equivalents for the synthesis of aldosterone (1990), Biochem. Biophys. Res. Commun., 170, 1256-1262.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
malate plus NADP+ and in synergism with ascorbate plus NADH increase of aldosterone synthetase activity in zona glomerulosa, no stimulation of 11beta-/18-hydroxylation Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
ascorbate without NADH, inhibition of aldosterone synthetase Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion from zona fasciculata Bos taurus 5739
-
mitochondrion from zona glomerulosa and fasciculata Bos taurus 5739
-
mitochondrion from zona glomerulosa Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11beta-hydroxysteroid + 2 oxidized adrenodoxin + H2O for synthesis of aldosterone 3 molecules P450 must be reduced or one molecule must be reduced 3 times Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + 2 H+ + 2 O2 3 steps in glomerulosa catalysed by one enzyme, 11beta-hydroxylation to corticosterone, 18-hydroxylation to 18-hydroxycorticosterone and aldehyde synthesis to aldosterone Bos taurus aldosterone + oxidized adrenal ferredoxin + 2 H2O
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ascorbate plus NADH very low conversion and no aldosterone production, in synergism with NADH, malate and NADP+ increase of aldosterone synthetase activity in zona glomerulosa, not zona fasciculate Bos taurus
NADH
-
Bos taurus
NADP+ plus malate supports all 4 conversions, increase of aldosterone synthetase activity Bos taurus
NADPH
-
Bos taurus