Cloned (Comment) | Organism |
---|---|
cDNA transfected into COS-7 cells simultaneously with bovine adrenodoxin cDNA expression plasmid | Ovis aries |
Protein Variants | Comment | Organism |
---|---|---|
additional information | all enzymes with aldosterone synthesis activity have a glycine residue at position 288, in nonaldosterone synthesising P45011beta it is valine or serine | Ovis aries |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | conversion of labelled steroid to labelled aldosterone is inhibited by the addition of an excess of the same unlabelled steroid | Ovis aries |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | from zona fasciculata | Ovis aries | 5739 | - |
mitochondrion | from zona reticularis | Ovis aries | 5739 | - |
mitochondrion | from zona glomerulosa | Ovis aries | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | Ovis aries | 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis | corticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 | Ovis aries | 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
corticosterone + reduced adrenal ferredoxin + O2 | Ovis aries | 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis | 18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | 11beta-hydroxylation | Ovis aries | corticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | 11beta-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis | Ovis aries | corticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxy-corticosterone + reduced adrenal ferredoxin + O2 | 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis | Ovis aries | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Ovis aries | aldosterone + oxidized adrenal ferredoxin + H2O | 18-hydroxylation | ? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Ovis aries | aldosterone + oxidized adrenal ferredoxin + H2O | aldosterone production exclusively in the zona glomerulosa | ? | |
corticosterone + reduced adrenal ferredoxin + O2 | 18-hydroxylation | Ovis aries | 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
corticosterone + reduced adrenal ferredoxin + O2 | 18-hydroxylation, last 3 steps of pathway for aldosterone biosynthesis | Ovis aries | 18-hydroxy-corticosterone + oxidized adrenal ferredoxin + H2O | - |
? |