Inhibitors | Comment | Organism | Structure |
---|---|---|---|
metyrapol | 11beta-hydroxylase inhibition, 40.8% by racemate, 38.1% by (+)-enantiomer and 33.8% by (-)-enantiomer, each 0.4 mM | Rattus norvegicus | |
Metyrapone | 11beta-hydroxylase, 39.7% inhibition by 0.4 mM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
plasma | pharmacokinetics of metyrapone and metyrapol | Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00968 | - |
+/-0.00126, 40.8% inhibition by 0.4 mM metyrapol, adrenal tissue | Rattus norvegicus |
0.00986 | - |
+/-0.00044, 39.7% inhibition by 0.4 mM metyrapone, adrenal tissue | Rattus norvegicus |
0.01011 | - |
+/-0.00126, 38.1% inhibition by 0.4 mM (+)-metyrapol, adrenal tissue | Rattus norvegicus |
0.01081 | - |
+/-0.00269, 33.8% inhibition by 0.4 mM (-)-metyrapol, adrenal tissue | Rattus norvegicus |
0.01633 | - |
+/-0.00237, no inhibitor, adrenal tissue | Rattus norvegicus |
Storage Stability | Organism |
---|---|
blood samples, 4°C | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | adrenal | Rattus norvegicus | corticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
metyrapone + ? | plasma, product-stereoselective reductive metabolism | Rattus norvegicus | metyrapol + ? | enantiomers | r |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |