Cloned (Comment) | Organism |
---|---|
full-length P45011B1 cDNA cloned into and expressed in lung fibroblast derived V79 Chinese hamster cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clotrimazole | azole derivative, antimycotic drug, strong dose-dependent inhibition | Homo sapiens | |
ketoconazole | azole derivative, antimycotic drug, strong dose-dependent inhibition | Homo sapiens | |
Metyrapone | diagnostic inhibitor, strong inhibition, 0.02 mM complete inhibition | Homo sapiens | |
miconazole | azole derivative, antimycotic drug, strong dose-dependent inhibition | Homo sapiens | |
spironolactone | diuretic and antihypertensive drug, competitive aldosterone antagonist, slight inhibition | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
55555 | - |
x * 55555, calculated from full-length cDNA of 1.5 kb | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 | 11beta-hydroxylation | Homo sapiens | corticosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
11-deoxycortisol + reduced adrenal ferredoxin + O2 | 11beta-hydroxylation | Homo sapiens | cortisol + oxidized adrenal ferredoxin + H2O | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 55555, calculated from full-length cDNA of 1.5 kb | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
- |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
- |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | adrenodoxin and adrenodoxin reductase required in cell line homogenates, in living cells in absence of cofactors | Homo sapiens |