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Literature summary for 1.14.15.4 extracted from

  • Denner, K.; Vogel, R.; Schmalix, W.; Doehmer, J.; Bernhardt, R.
    Cloning and stable expression of the human mitochondrial cytochrome P45011B1 cDNA in V79 Chinese hamster cells and their application for testing of potential inhibitors (1995), Pharmacogenetics, 5, 89-96.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
full-length P45011B1 cDNA cloned into and expressed in lung fibroblast derived V79 Chinese hamster cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
clotrimazole azole derivative, antimycotic drug, strong dose-dependent inhibition Homo sapiens
ketoconazole azole derivative, antimycotic drug, strong dose-dependent inhibition Homo sapiens
Metyrapone diagnostic inhibitor, strong inhibition, 0.02 mM complete inhibition Homo sapiens
miconazole azole derivative, antimycotic drug, strong dose-dependent inhibition Homo sapiens
spironolactone diuretic and antihypertensive drug, competitive aldosterone antagonist, slight inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55555
-
x * 55555, calculated from full-length cDNA of 1.5 kb Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycorticosterone + reduced adrenal ferredoxin + O2 11beta-hydroxylation Homo sapiens corticosterone + oxidized adrenal ferredoxin + H2O
-
?
11-deoxycortisol + reduced adrenal ferredoxin + O2 11beta-hydroxylation Homo sapiens cortisol + oxidized adrenal ferredoxin + H2O
-
?

Subunits

Subunits Comment Organism
? x * 55555, calculated from full-length cDNA of 1.5 kb Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH adrenodoxin and adrenodoxin reductase required in cell line homogenates, in living cells in absence of cofactors Homo sapiens