Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.15.4 extracted from

  • Ulmschneider, S.; Muller-Vieira, U.; Klein, C.D.; Antes, I.; Lengauer, T.; Hartmann, R.W.
    Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase (2005), J. Med. Chem., 48, 1563-1575.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-[(Z)-2,3-dihydro-1H-inden-1-ylidenemethyl]pyridine 50% inhibition at 0.087 mM Homo sapiens
4-[(Z)-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)methyl]pyridine 50% inhibition at 0.034 mM, selective for CYP11B1 Homo sapiens
5-[(1E)-1-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)ethyl]isoquinoline 50% inhibition at 0.096 mM Homo sapiens
5-[(E)-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)methyl]isoquinoline 50% inhibition at 0.058 mM, selective for CYP11B1 Homo sapiens
5-[(E)-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)methyl]pyrimidine 50% inhibition at 0.027 mM, very selective for CYP11B1 Homo sapiens
5-[(Z)-(5-fluoro-2,3-dihydro-1H-inden-1-ylidene)methyl]isoquinoline 50% inhibition at 0.026 mM, selective for CYP11B1 Homo sapiens
fadrozole 50% inhibition at 0.001 mM Homo sapiens
ketoconazole 50% inhibition at 0.081 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-