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Literature summary for 1.14.15.4 extracted from

  • Ulmschneider, S.; Muller-Vieira, U.; Mitrenga, M.; Hartmann, R.W.; Oberwinkler-Marchais, S.; Klein, C.D.; Bureik, M.; Bernhardt, R.; Antes, I.; Lengauer, T.
    Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase (2005), J. Med. Chem., 48, 1796-1805.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(5Z)-5-(1H-imidazol-5-ylmethylene)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile 50% inhibition at 0.0069 mM, selective for CYP11B1 Homo sapiens
5-[(Z)-2,3-dihydro-1H-inden-1-ylidenemethyl]-1H-imidazole 50% inhibition at 0.0061 mM Homo sapiens
5-[(Z)-3,4-dihydronaphthalen-1(2H)-ylidenemethyl]-1H-imidazole 50% inhibition at 0.0033 mM Homo sapiens
fadrozole 50% inhibition at 0.010 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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