Cloned (Comment) | Organism |
---|---|
genes CYP11B1 and CYP11B2, DNA and amino acid sequence determination and analysis, expression of wild-type and mutant enzymes in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
G314R/Q43R/V386A | naturally occuring mutant isolated from a patient with adrenal hyperplasia, gene structure, overview, CYP11B1 deficiency is caused by compound heterozygosity for mutation G314R of one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele, the PSV11 beta2-beta1 chimera dioes not have 18-hydroxylase/oxidase activity, but shows 11beta-hydroxylase activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
aldosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P15538 | cytochrome P450 11B1, mitochondrial precursor | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
zona fasciculata | CYP11B1 expression | Homo sapiens | - |
zona reticulata | CYP11B1 expression | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CYP11B1 | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
cytochrome P450 11B1 | - |
Homo sapiens |
Steroid 11-beta-hydroxylase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced adrenal ferredoxin | - |
Homo sapiens |