Cloned (Comment) | Organism |
---|---|
gene CYP11B1, DNA and amino acid sequence determination and analysis, localization on chromosome 8 adjacent to gene CYP11B2, genotyping and determination of polymorphisms in 1428 samples of Caucasian families, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, genotyping, linkages of polymorphisms in CYP11B1, at exon1, intron 3, and exon 8, and CYP11B2, phenotypes, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
additional information | Homo sapiens | genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + NADPH + O2 | - |
Homo sapiens | cortisol + NADP+ + H2O | - |
? | |
11-deoxycortisol + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
additional information | genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11-beta hydroxylase | - |
Homo sapiens |
Aldosterone synthase | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
reduced adrenal ferredoxin | - |
Homo sapiens |