Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.15.4 extracted from

  • Keavney, B.; Mayosi, B.; Gaukrodger, N.; Imrie, H.; Baker, M.; Fraser, R.; Ingram, M.; Watkins, H.; Farrall, M.; Davies, E.; Connell, J.
    Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion (2005), J. Clin. Endocrinol. Metab., 90, 1072-1077.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CYP11B1, DNA and amino acid sequence determination and analysis, localization on chromosome 8 adjacent to gene CYP11B2, genotyping and determination of polymorphisms in 1428 samples of Caucasian families, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, genotyping, linkages of polymorphisms in CYP11B1, at exon1, intron 3, and exon 8, and CYP11B2, phenotypes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-deoxycortisol + reduced adrenal ferredoxin + O2 Homo sapiens
-
cortisol + oxidized adrenal ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 Homo sapiens
-
aldosterone + oxidized adrenal ferredoxin + H2O
-
?
additional information Homo sapiens genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycortisol + NADPH + O2
-
Homo sapiens cortisol + NADP+ + H2O
-
?
11-deoxycortisol + reduced adrenal ferredoxin + O2
-
Homo sapiens cortisol + oxidized adrenal ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
Homo sapiens aldosterone + oxidized adrenal ferredoxin + H2O
-
?
additional information genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor 11-deoxycortisol urinary metabolite excretion, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
11-beta hydroxylase
-
Homo sapiens
Aldosterone synthase
-
Homo sapiens
CYP11B2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
reduced adrenal ferredoxin
-
Homo sapiens