Protein Variants | Comment | Organism |
---|---|---|
additional information | genotyping of 573 members of 105 British Caucasian families, geno- and phenotype, nine diallelic polymorphisms, overview, association between aldosterone production and variation in gene CYP11B1, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | Homo sapiens | CYP11B1 | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | Homo sapiens | CYP11B2 | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
573 members of 105 British Caucasian families, genes CYP11B1 and CYP11B2 | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
urinary steroid analyses | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | CYP11B1 | Homo sapiens | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | CYP11B2 | Homo sapiens | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxylase | - |
Homo sapiens |
Aldosterone synthase | - |
Homo sapiens |
CYP11B1 | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
steroid 11beta-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced adrenal ferredoxin | - |
Homo sapiens |