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Literature summary for 1.14.15.4 extracted from

  • Imrie, H.; Freel, M.; Mayosi, B.M.; Davies, E.; Fraser, R.; Ingram, M.; Cordell, H.J.; Farrall, M.; Avery, P.J.; Watkins, H.; Keavney, B.; Connell, J.M.
    Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene (2006), J. Clin. Endocrinol. Metab., 91, 5051-5056.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information genotyping of 573 members of 105 British Caucasian families, geno- and phenotype, nine diallelic polymorphisms, overview, association between aldosterone production and variation in gene CYP11B1, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-deoxycortisol + reduced adrenal ferredoxin + O2 Homo sapiens CYP11B1 cortisol + oxidized adrenal ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 Homo sapiens CYP11B2 aldosterone + oxidized adrenal ferredoxin + H2O
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
573 members of 105 British Caucasian families, genes CYP11B1 and CYP11B2
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
urinary steroid analyses Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycortisol + reduced adrenal ferredoxin + O2 CYP11B1 Homo sapiens cortisol + oxidized adrenal ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 CYP11B2 Homo sapiens aldosterone + oxidized adrenal ferredoxin + H2O
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxylase
-
Homo sapiens
Aldosterone synthase
-
Homo sapiens
CYP11B1
-
Homo sapiens
CYP11B2
-
Homo sapiens
steroid 11beta-hydroxylase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
reduced adrenal ferredoxin
-
Homo sapiens