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Literature summary for 1.14.15.4 extracted from

  • Mueller-Vieira, U.; Angotti, M.; Hartmann, R.W.
    The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors (2005), J. Steroid Biochem. Mol. Biol., 96, 259-270.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fadrozole in vitro and in vivo inhibition Homo sapiens
additional information effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-deoxycortisol + reduced adrenal ferredoxin + O2 Homo sapiens
-
cortisol + oxidized adrenal ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 Homo sapiens
-
aldosterone + oxidized adrenal ferredoxin + H2O
-
?
additional information Homo sapiens effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
NCI-H295R cell adrenocortical tumor cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxycortisol + reduced adrenal ferredoxin + O2
-
Homo sapiens cortisol + oxidized adrenal ferredoxin + H2O
-
?
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2
-
Homo sapiens aldosterone + oxidized adrenal ferredoxin + H2O
-
?
additional information effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
Aldosterone synthase
-
Homo sapiens
CYP11B1
-
Homo sapiens
CYP11B2
-
Homo sapiens
steroid-11beta-hydroxylase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
reduced adrenal ferredoxin
-
Homo sapiens