Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fadrozole | in vitro and in vivo inhibition | Homo sapiens | |
additional information | effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | Homo sapiens | - |
aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
additional information | Homo sapiens | effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
NCI-H295R cell | adrenocortical tumor cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxycortisol + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | cortisol + oxidized adrenal ferredoxin + H2O | - |
? | |
18-hydroxycorticosterone + reduced adrenal ferredoxin + O2 | - |
Homo sapiens | aldosterone + oxidized adrenal ferredoxin + H2O | - |
? | |
additional information | effects of enzyme inhibition of steroid biosynthesis and mineralcorticoid formation, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aldosterone synthase | - |
Homo sapiens |
CYP11B1 | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
steroid-11beta-hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
reduced adrenal ferredoxin | - |
Homo sapiens |