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Literature summary for 1.14.15.4 extracted from

  • Wang, X.G.; Orban, L.
    Anti-Muellerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males (2007), Dev. Dyn., 236, 1329-1338.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information genes amh and cyp11b are both upregulated during juvenile ovary-to-testis transformation Danio rerio

Cloned(Commentary)

Cloned (Comment) Organism
gene cyp11b, sequence comparison and expression analysis Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Danio rerio the enzyme is involved in gonadal transformation in the zebrafish, enzyme expression regulation, overview ?
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?

Organism

Organism UniProt Comment Textmining
Danio rerio A1XRK1 gene cyp11b, a protogynous hermaphroditic fish
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Danio rerio
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eye
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Danio rerio
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gonad during development all zebrafish males first develop a juvenile ovary, that later degenerates and transforms into a testis, the enzyme is involved, but not inducing, in gonadal transformation in the zebrafish, but its localization is not related to the position of degenerating oocytes, overview Danio rerio
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gut
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Danio rerio
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heart
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Danio rerio
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kidney
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Danio rerio
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liver
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Danio rerio
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additional information the mRNA of cyp11b is detected in all the adult organs tested Danio rerio
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muscle higher enzyme expression level Danio rerio
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ovary
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Danio rerio
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skin
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Danio rerio
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testis very high expression level Danio rerio
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
corticosterone + reduced adrenal ferredoxin + O2
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Danio rerio 11-deoxycorticosterone + adrenal ferredoxin + ?
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?
additional information the enzyme is involved in gonadal transformation in the zebrafish, enzyme expression regulation, overview Danio rerio ?
-
?

Synonyms

Synonyms Comment Organism
11 beta-hydroxylase
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Danio rerio
cyp11beta
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Danio rerio
P45011beta
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Danio rerio

Cofactor

Cofactor Comment Organism Structure
reduced adrenal ferredoxin
-
Danio rerio