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Literature summary for 1.14.15.4 extracted from

  • Chen, K.; Tong, W.; Wei, D.; Jiang, W.
    The 11beta-hydroxylation of 16,17alpha-epoxyprogesterone and the purification of the 11beta-hydroxylase from Absidia coerulea IBL02 (2007), Enzyme Microb. Technol., 41, 71-79.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information progesterone induces the enzyme Absidia caerulea

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
Absidia caerulea
Mg2+
-
Absidia caerulea
Mn2+
-
Absidia caerulea
Zn2+
-
Absidia caerulea

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ highly activating Absidia caerulea
Fe2+ highly activating Absidia caerulea

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
x * 60000, SDS-PAGE Absidia caerulea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2 Absidia caerulea
-
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O the product is an important intermediate for many anti-inflammatory drugs ?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2 Absidia caerulea IBL02
-
11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O the product is an important intermediate for many anti-inflammatory drugs ?

Organism

Organism UniProt Comment Textmining
Absidia caerulea
-
-
-
Absidia caerulea IBL02
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme by anion exchange and hydrophobic interaction chromatography, and two additonal steps of anion exchange chromatography Absidia caerulea

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Absidia caerulea
-

Storage Stability

Storage Stability Organism
-20°C, purified enzyme, 24 h, addition of 20% glycerol, 0.5 mM PMSF, 0.5 mM DTT, 95.3% remaining activity Absidia caerulea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
-
Absidia caerulea 11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O the product is an important intermediate for many anti-inflammatory drugs ?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2 assay optimization Absidia caerulea 11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
-
?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2
-
Absidia caerulea IBL02 11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O the product is an important intermediate for many anti-inflammatory drugs ?
16,17alpha-epoxyprogesterone + reduced adrenal ferredoxin + O2 assay optimization Absidia caerulea IBL02 11beta-hydroxy-16,17alpha-epoxyprogesterone + adrenal ferredoxin + H2O
-
?

Subunits

Subunits Comment Organism
? x * 60000, SDS-PAGE Absidia caerulea

Synonyms

Synonyms Comment Organism
11beta-hydroxylase
-
Absidia caerulea

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Absidia caerulea

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30
-
purified enzyme, loss of 75% activity after 3 h, and of all activity after 8 h Absidia caerulea

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Absidia caerulea

Cofactor

Cofactor Comment Organism Structure
additional information cofactor screening, overview, the enzyme is active with NADPH Absidia caerulea
reduced adrenal ferredoxin
-
Absidia caerulea