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Literature summary for 1.14.15.4 extracted from

  • Zhao, L.Q.; Han, S.; Tian, H.M.
    Progress in molecular-genetic studies on congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency (2008), World J. Pediatr., 4, 85-90.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence analysis, expression analysis and regulation Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information determination and analysis of naturally occuring mutant enzyme variants and their phenotypes, construction of chimeric enzymes with 21-hydroxylase, gene CYP11B2, detailed overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens deficiency of 11beta-hydroxylase results in decreased synthesis of cortisol and glucocorticoids, and thus causes weakened depressive feedback ofACTH and increased synthesis of ACTH in pituitary, which leads to production of more cortisol precursor in zona fasciculata, enzyme regulation, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland zona glomerulosa Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information deficiency of 11beta-hydroxylase results in decreased synthesis of cortisol and glucocorticoids, and thus causes weakened depressive feedback ofACTH and increased synthesis of ACTH in pituitary, which leads to production of more cortisol precursor in zona fasciculata, enzyme regulation, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxylase
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Homo sapiens
cytochrome P45011beta
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Homo sapiens