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Literature summary for 1.14.15.4 extracted from

  • Imachi, H.; Murao, K.; Cao, W.M.; Muraoka, T.; Nishiuchi, T.; Dobashi, H.; Hosomi, N.; Iwama, H.; Ishida, T.
    The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene (2008), Biochem. Biophys. Res. Commun., 376, 531-535.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus prolactin regulatory element-binding (PREB) protein. It regulates the transcription of the CYP11B1 gene via cAMP. PREB can function as a transcriptional regulator of the CYP11B1 promoter. PREB binds to the CYP11B1 promoter, and in cells expressing PREB, it increases CYP11B1 expression. Knockdown of PREB expression attenuated the effects of cAMP on CYP11B1 expression. CYP11B1 promoter activity is increased in the cells treated with the scrambled siRNA and cAMP, while the CYP11B1 promoter activity is markedly reduced in the cells treated with the PREB-specific siRNA. Enzyme is regulated by cAMP, which stimulates the expression of PREB. Knockdown of PREB expression attenuates the effects of cAMP on CYP11B1 expression ?
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additional information Mus musculus responsible for the last step of glucocorticoid biosynthesis in the adrenal cortices of many kinds of animals ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
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Mus musculus
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Y-1 cell adrenocortical tumor cell line Y-1 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information prolactin regulatory element-binding (PREB) protein. It regulates the transcription of the CYP11B1 gene via cAMP. PREB can function as a transcriptional regulator of the CYP11B1 promoter. PREB binds to the CYP11B1 promoter, and in cells expressing PREB, it increases CYP11B1 expression. Knockdown of PREB expression attenuated the effects of cAMP on CYP11B1 expression. CYP11B1 promoter activity is increased in the cells treated with the scrambled siRNA and cAMP, while the CYP11B1 promoter activity is markedly reduced in the cells treated with the PREB-specific siRNA. Enzyme is regulated by cAMP, which stimulates the expression of PREB. Knockdown of PREB expression attenuates the effects of cAMP on CYP11B1 expression Mus musculus ?
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?
additional information responsible for the last step of glucocorticoid biosynthesis in the adrenal cortices of many kinds of animals Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxylase
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Mus musculus
CYP11B1 member of the cytochrome p-450 superfamily Mus musculus