Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol | - |
Homo sapiens | |
(1S)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol | - |
Homo sapiens | |
2-(4-chlorobenzyl)-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-(4-fluorobenzyl)-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-benzyl-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-[(1R)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(3-methoxy-2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(cyclopropylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(3-methyloxetan-3-yl)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(propan-2-yloxy)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
3-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-2-methylpropan-1-ol | - |
Homo sapiens | |
4-(2-methylpropyl)-2-(thiophen-2-ylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
4-(2-methylpropyl)-2-[4-(trifluoromethoxy)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
4-(2-methylpropyl)-2-[4-(trifluoromethyl)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | - |
Homo sapiens | |
4-(7-benzyl-6-oxo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-5-yl)benzonitrile | - |
Homo sapiens | |
FAD286 | inhibitor of 11-beta-hydroxylase CYP11B1 | Homo sapiens | |
fadrozole | inhibitor of CYP11B2 | Homo sapiens | |
additional information | a sulfonamide-imidazole scaffold is a potent inhibitor of CYP11B2, the scaffold can achieve high levels of selectivity for CYP11B2 over CYP11B1, overview. Evaluation of a lactam series of derivatives of the R-enantiomer of fadrozole, FAD286, homology modelling, overview | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
zona glomerulosa | cells of the adrenal gland express CYP11B2 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
11-beta-hydroxylase | - |
Homo sapiens |
Aldosterone synthase | - |
Homo sapiens |
CYP11B1 | - |
Homo sapiens |
CYP11B2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000003 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1S)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol | |
0.0000007 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(3-methoxy-2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000008 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(propan-2-yloxy)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000013 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(cyclopropylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000024 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (1R)-2-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-1-phenylethanol | |
0.0000052 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-(4-chlorobenzyl)-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000078 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-[(3-methyloxetan-3-yl)methyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000094 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(1R)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000114 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 3-[2-[(1S)-1-(4-chlorophenyl)ethyl]-3,3-dioxido-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazin-4-yl]-2-methylpropan-1-ol | |
0.0000186 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-benzyl-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.0000617 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(1S)-1-(4-chlorophenyl)ethyl]-4-(2-methylpropyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.000104 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-(2-methylpropyl)-2-[4-(trifluoromethoxy)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.000117 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-(2-methylpropyl)-2-(thiophen-2-ylmethyl)-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide | |
0.000121 | - |
inhibition of CYP11B2, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 4-(2-methylpropyl)-2-[4-(trifluoromethyl)benzyl]-1,2-dihydroimidazo[5,1-d][1,2,5]thiadiazine 3,3-dioxide |
General Information | Comment | Organism |
---|---|---|
metabolism | CYP11B1 is a key enzyme in the biosynthesis of cortisol. CYP11B2 catalyzes the last three steps of aldosterone biosynthesis | Homo sapiens |