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Literature summary for 1.14.15.4 extracted from

  • Saha, S.; Bornstein, S.R.; Graessler, J.; Kopprasch, S.
    Very-low-density lipoprotein mediates transcriptional regulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways (2012), Cell Tissue Res., 348, 71-80.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal cortex
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Homo sapiens
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adrenocortical carcinoma cell
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Homo sapiens
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NCI-H295R cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a steroid + reduced adrenodoxin + O2
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Homo sapiens an 11beta-hydroxysteroid + oxidized adrenodoxin + H2O
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?

Synonyms

Synonyms Comment Organism
Aldosterone synthase
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Homo sapiens

Cofactor

Cofactor Comment Organism Structure
adrenodoxin
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens native very-low-density lipoprotein as well as glycoxidized VLDL, but not oxidized VLDL, mediate transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Very-low-density lipoprotein , irrespective of modification, presumably recruits PKA, ERK1/2 and Jak-2 for steroid hormone release through modulation of Cyp11B2 mRNA level up

General Information

General Information Comment Organism
metabolism very-low-density lipoprotein mediates transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Aldosterone, apart from its role in fluid and electrolyte homeostasis, is implicated in insulin resistance and myocardial fibrosis. Impact of VLDL as a potential risk factor for aldosterone-mediated cardiovascular injury in diabetes mellitus, intracellular mechanism, overview Homo sapiens