Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal cortex | - |
Homo sapiens | - |
adrenocortical carcinoma cell | - |
Homo sapiens | - |
NCI-H295R cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
a steroid + reduced adrenodoxin + O2 | - |
Homo sapiens | an 11beta-hydroxysteroid + oxidized adrenodoxin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Aldosterone synthase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
adrenodoxin | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | native very-low-density lipoprotein as well as glycoxidized VLDL, but not oxidized VLDL, mediate transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Very-low-density lipoprotein , irrespective of modification, presumably recruits PKA, ERK1/2 and Jak-2 for steroid hormone release through modulation of Cyp11B2 mRNA level | up |
General Information | Comment | Organism |
---|---|---|
metabolism | very-low-density lipoprotein mediates transcriptional upregulation of aldosterone synthase in human adrenocortical cells through multiple signaling pathways, e.g. partially through scavenger receptor class B type I. Aldosterone, apart from its role in fluid and electrolyte homeostasis, is implicated in insulin resistance and myocardial fibrosis. Impact of VLDL as a potential risk factor for aldosterone-mediated cardiovascular injury in diabetes mellitus, intracellular mechanism, overview | Homo sapiens |